It's looking like Hyperhomocysteinemia from an MTHFR mutation

[Tack]

My labs came back, I don’t know what it all means yet. I have another appointment with my doctor to go over the results. Everything came back normal except two things. They confirmed two C677T mutations, and I have high homocysteine levels. This is all pointing to hyperhomocysteinemia, which is likely the cause of my blood clot, DVT, pulmonary embolism.

The 4 listed causes of this condition, vitamin B deficiency, alcohol, tobacco, and this particular genetic mutation. The first 3 I’m far away from, so I’m left with the last on the list. Some other long term conditions to follow are higher risk of renal diseases, and vascular diseases. I’m thinking the high cholesterol on my previous labs, might be due to this same condition. I’m reading a lot of citations of high homocysteine leading to buildup of plaque on the arteries. Just would be a question for the doc.

Also, I wouldn’t worry too much about the AST ALT levels, blood thinners can cause elevated levels, up to 3x the normal levels. Not to say blood thinners can’t cause liver damage on the long term, but I’m sure my docs are aware of all this, and there will be plenty more appointments to come.

I’m not looking for medical advise, but I’m interested in knowing peoples thoughts, especially in context of vascular/hematology health and steroid usage. I’m still trying to evaluate how exactly this impacts my life, and I’m not sure what questions I should be asking, but I’ll try with a couple

Is there any helpful advise, or things I should consider when and if deciding to try a cycle?

If I were to be on blood thinners for the rest of my life, how would something like that be managed, taking steroids + on thinners? Is it even possible?

I know I’ve heard of drug interactions, but doing some research, it all falls back to some medical advisory letters way back when saying it has the potential to cause blood thinners to work more effectively, which can be a bad thing. But the validity of this information is up in the air, as there have only been a few hospital observations, no actual studies.

Lets say I can jump off blood thinners, I’m still at higher risk for clots. What are some ways to prevent clotting while on steroids?

Any thoughts are welcomed.

 

[herrubermensch]

Only contribution I can make is to to confirm that your AST/ALT levels are NOT EVEN “moderately elevated,” which is a phrase of art meaning “two to three times the reference range.”

 

[Tack]

The doctor has the lab results, I’m sure if there were major concerns I’d be getting phonecalls. It will be something I’ll be bringing up next appointment though

 

[NeuroRN]

Too be honest, I’d be perfectly honest with your doctor about wanting to start AAS. there’s potential for some serious effects. I don’t know, this is wayyyyyyyy outside my scope.

 

[Tack]

Yeah, I intend to. This is the first time I’ve had doctors I can be blunt with, and get straight answers. This is also my first experience in getting treatment from a cancer center, instead of a general practice place. I think that might have something to do with it.

 

[Dirtnasty]

I don’t want what mthfr is other than maybe something I’ve been called and rightfully so. Haha I do sleep with woman who have kids

 

[Tack]

Lol, Okay that was a good one.

 

[Kad1]

I’m with @NeuroRN on this. Way above my pay grade. I will say I know there is some correlation to steroids and strokes not too sure how that would relate to your issue and honestly I don’t even k ow a doc I would trust to give you and accurate answer.
I’d at least be on higher doses of fish oil and an aspirin but gotta talk to your doc. I’d probably seek the advise of an endocrinologist, maybe your best bet

 

[NeuroRN]

I think that’s a great idea. They would probably give you the best answer.

 

[Tack]

I actually have a better way to phrase my question to y’all.

What additional questions do you think would be best for me to ask my doctor about?

I could also make this a little more fun, and ask any questions out of pure curiosity, within reason of course, and follow up with his responses next time I visit.

 

[JLee]

Not to say blood thinners can’t cause liver damage on the long term, but I’m sure my docs are aware of all this, and there will be plenty more appointments to come.

Never assume your doctor knows all. I would definitely ask to be sure. Just my 2 cents.

 

[Poppy]

Brother…you’re in the deep end of the pool.

At this point… my opinion is be as frank and forthcoming with your doc about aas.

 

[Poppy]

higher risk of renal diseases,

Just reread your post. Brother this stuff you’re dealing with is putting a large (dangerous) multiplying factor on use of aas.

 

[Tack]

Yeah I understand. And I do heed everyone’s warning. I’m not rushing into anything. I still have a lot of time to invest in burning fat, and if my test really is on the high level to begin with, I shouldn’t have a problem becoming a fairly reasonable size without aas.

I have multiple visits with multiple doctors, going to add an endocrinologist on the list way before aas.

I figured it would be a shot in the dark asking questions on this topic, but thought I’d throw it out there anyway.

 

[Bigmurph6]

Im glad to hear that brother you being safe and watching your health great Harm Reduction

 

[Tack]

I’m following up as I learn more information others could provide useful. From what I’ve gathered with blood thinners, is that it’s taxing on the liver, which aas would only exacerbate, and that blood thinners will provide inaccurate blood test results in a multitude of areas, this is why a lot of blood labs are on hold till my blood thinner treatments are over. So even if I wanted to juice up, I can’t trust my blood work beyond what my tiny bit of medical knowledge I have.

For hyperhomocysteinemia-expialidocious, Well I don’t trust my judgement to give any further words on the subject. I’m half tempted to ask for this thread to just be locked, as anymore info that could be provided is all medical advise.

tl;dr It’s complicated, ask a doctor.