How It Works – HGH To IGF-1 Pathway

[blair]

1. You inject HGH (Somatropin)
This increases growth hormone levels in the bloodstream.

2. Liver response:
The liver responds to HGH by producing IGF-1.

3. IGF-1 Actions:
• Promotes muscle cell growth and repair
• Stimulates fat breakdown (lipolysis)
• Enhances protein synthesis
• Supports bone and joint health
• Increases insulin sensitivity (in moderate doses)



Key Points to Know:
• HGH is the signal, but IGF-1 is the workhorse behind most of the effects athletes want.

• The IGF-1 produced in the liver is called systemic IGF-1.

• HGH also has direct effects (e.g., fat loss, fluid retention), but muscle growth is largely IGF-1 driven.

Fun Fact:
Some athletes directly inject IGF-1 LR3 or IGF-1 DES for localized growth, bypassing the HGH-liver step.

 

[blair]

What is Growth Hormone, and why does it matter?
Produced by the pituitary gland, GH plays a critical role in how our bodies grow, recover, and function.

It helps increase height in kids
Builds muscle and bone strength
Aids fat loss and boosts metabolism
Sometimes even used post-surgery to support recovery

But here’s the key — it’s powerful, and it must be used under medical supervision.

 

[blair]

 

[blair]