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I think that’s kinda the million dollar question lol, no one really knows exactly how it causes issues like gyno or estrogenic type sides we know for sure it doesn’t aromatise or convert to progesterone but they did find evidence that it stimulates the estrogen receptors but even then there’s not a whole lot of explanation of that really means even but as rule of thumb when u have typical estrogen sides like gyno or tightness in low back running an AI like adex or aromasin relieves some of that I really don’t know if it’s due to the stimulation of the estrogen receptor like a few places have reported or just a synergistic effect with the other compounds your running that cause elevation in your overall estrogen numbers but I do know an AI will help some when you start to have those type issues. Also when running anadrol keeping your blood pressure in check with a blood pressure med combined with hctz to keep water retention down can help with tightness from bloat some also.