Bigmurph6
Banned
GAAKA or Glycine-Arginine-Alpha-Ketoisocaproate acid
sin. Glycine-Arginine-Alpha-Ketoisocaproate
**PERFORMANCE VALIDATION SCORES
Combined 7
Clinical Support Rating 4
Empirical Evidence Rating 3
Description
Glycine-arginine-alpha-ketoisocaproic
acid GAAKA) is an arginine and glycine salt of alpha-ketoisocaproic acid, a metabolite of L-leucine. The body will metabolize this compound into free arginine.
alpha-ketoisocaproate, and glycine. Arginine is involved in a number of biological activities important to athletic performance, including protein synthesis, ammonia detoxification, nitric oxide production, growth hormone release, and the synthesis of creatine phosphate. Ketoisocaproate has been speculated to
improve anaerobic energy metabolism, and buffer exercise induced muscle damage Glycine is a nonessential amino acid involved in growth hormone synthesis, and may reduce muscle fatigue. GAAKA appears to reduce muscle fatigue and improve performance when taken prior to exercise.
Promoted Benefits
Glycine-arginine-alpha-ketoisocaproic acid is pro-
moted to reduce ammonia levels and improve muscle stamina during intense exercise.
Clinical Studies
This ingredient has been shown to improve performance in placebo-controlled studies with untrained adults. It has a Clinical Support Rating of 4 (4/5).
One study involved the single-dose supplementation
of GAAKA in a group of healthy subjects prior to exercise. Muscle performance was measured with a series of three sets of knee concentric and eccentric contractions, which were conducted over a 15-minute period (five minutes of rest between sets). The supplementation of GAAKA was shown to increase the resistance to fatigue by 14-28% over the 3 sets, and total work by 9-12% (average 10.5%), compared to
placebo. A second study also examined the effects of a single dose of GAAKA prior to exercise, which was taken by a group of healthy men… The dosage administered was 11.2 g, which was consumed during a 45 minute period prior to exercise. The exercise protocol
involved a series (five) of 10-second cycle ergometer sprints against high resistance. Evaluations were made of mean muscle power, peak power, serum lactate, and fatigue values. Subjects taking GAAKA noticed a greater retention of mean power between the
first and second sprints. No other variables were significantly different from placebo.
These studies support the use of glycine arginine-alpha-ketoisocaproic acid as a sport supplement.
Empirical Evidence
Glycine-arginine-alpha-ketoisocaproic acid has been widely used as a stand-alone supplement. The feedback on this product has generally been mixed. Some users confirm that glycine-arginine-alpha-ketoisocaproic acid does improve muscle endurance and Stamina when taken before intense training. A fair percentage of these further report that this increase in stamina allows for greater levels of stimulation dur-
ing exercise, and thus enhanced results over time. The
improvements are not immense, however, but consistent. A seemingly equal percentage of users report dissatisfaction with the supplement, often claiming a lack of substantial improvement. Whether this is due to individual insensitivity to GAAKA or unrealistic
expectations remains unclear. Glycine-arginine-
alpha-ketoisocaproic acid has an Empirical EvidenceRating of 3 (3/5).
Effective Dosage
Based on clinical studies, a dosage of 11.2 grams is recommended once daily, prior to intense exercise.
Side Effects / Safety
Glycine-arginine-alpha-ketoisocaproic acid was well tolerated during clinical studies, with no significant side effects reported.
sin. Glycine-Arginine-Alpha-Ketoisocaproate
**PERFORMANCE VALIDATION SCORES
Combined 7
Clinical Support Rating 4
Empirical Evidence Rating 3
Description
Glycine-arginine-alpha-ketoisocaproic
acid GAAKA) is an arginine and glycine salt of alpha-ketoisocaproic acid, a metabolite of L-leucine. The body will metabolize this compound into free arginine.
alpha-ketoisocaproate, and glycine. Arginine is involved in a number of biological activities important to athletic performance, including protein synthesis, ammonia detoxification, nitric oxide production, growth hormone release, and the synthesis of creatine phosphate. Ketoisocaproate has been speculated to
improve anaerobic energy metabolism, and buffer exercise induced muscle damage Glycine is a nonessential amino acid involved in growth hormone synthesis, and may reduce muscle fatigue. GAAKA appears to reduce muscle fatigue and improve performance when taken prior to exercise.
Promoted Benefits
Glycine-arginine-alpha-ketoisocaproic acid is pro-
moted to reduce ammonia levels and improve muscle stamina during intense exercise.
Clinical Studies
This ingredient has been shown to improve performance in placebo-controlled studies with untrained adults. It has a Clinical Support Rating of 4 (4/5).
One study involved the single-dose supplementation
of GAAKA in a group of healthy subjects prior to exercise. Muscle performance was measured with a series of three sets of knee concentric and eccentric contractions, which were conducted over a 15-minute period (five minutes of rest between sets). The supplementation of GAAKA was shown to increase the resistance to fatigue by 14-28% over the 3 sets, and total work by 9-12% (average 10.5%), compared to
placebo. A second study also examined the effects of a single dose of GAAKA prior to exercise, which was taken by a group of healthy men… The dosage administered was 11.2 g, which was consumed during a 45 minute period prior to exercise. The exercise protocol
involved a series (five) of 10-second cycle ergometer sprints against high resistance. Evaluations were made of mean muscle power, peak power, serum lactate, and fatigue values. Subjects taking GAAKA noticed a greater retention of mean power between the
first and second sprints. No other variables were significantly different from placebo.
These studies support the use of glycine arginine-alpha-ketoisocaproic acid as a sport supplement.
Empirical Evidence
Glycine-arginine-alpha-ketoisocaproic acid has been widely used as a stand-alone supplement. The feedback on this product has generally been mixed. Some users confirm that glycine-arginine-alpha-ketoisocaproic acid does improve muscle endurance and Stamina when taken before intense training. A fair percentage of these further report that this increase in stamina allows for greater levels of stimulation dur-
ing exercise, and thus enhanced results over time. The
improvements are not immense, however, but consistent. A seemingly equal percentage of users report dissatisfaction with the supplement, often claiming a lack of substantial improvement. Whether this is due to individual insensitivity to GAAKA or unrealistic
expectations remains unclear. Glycine-arginine-
alpha-ketoisocaproic acid has an Empirical EvidenceRating of 3 (3/5).
Effective Dosage
Based on clinical studies, a dosage of 11.2 grams is recommended once daily, prior to intense exercise.
Side Effects / Safety
Glycine-arginine-alpha-ketoisocaproic acid was well tolerated during clinical studies, with no significant side effects reported.
