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GHRPs (growth-hormone releasing peptides) GHRP-6, GHRP-2, are synthetic peptides developed originally to stimulate growth hormone (GH) secretion.
Beyond their endocrine effects, there has been increasing evidence since the 1980s that these peptides may have cytoprotective (cell- and tissue-protecting) and cardioprotective roles (i.e., protecting heart tissue).
GHRPs bind at least two receptors: the classical GH-secretagogue receptor (GHS-R1a) and the receptor CD36.
Activation of CD36 by GHRPs triggers prosurvival signaling pathways, including PI3K/AKT1, which helps reduce cell death.
GHRPs reduce reactive oxygen species (ROS) spillover, enhance antioxidant defenses, and lower inflammation.
Some GHRPs exert anti-fibrotic effects by counteracting fibrogenic cytokines (so possibly reducing tissue scarring).
Due to these influences, GHRPs may help preserve organ/tissue function under stress (cardiac, neuronal, hepatic, gastrointestinal).
In cardiac, neuronal, gastrointestinal, and hepatic cells, GHRPs showed protective effects in multiple preclinical models.
GHRPs also have myotropic/anabolic effects: promoting anabolism (tissue building) and inhibiting catabolism (tissue breakdown) — e.g., partly via GH/IGF-1 axis but also perhaps via GH-independent mechanisms.
GHRPs represent a multifaceted pharmacological class: not just GH secretagogues, but tissue-protective, anti-inflammatory, anti-oxidative, and anti-fibrotic agents.
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