eazy
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SLU-PP-332 (CAS number 303760-60-3) is a synthetic small molecule that acts as an agonist of the estrogen-related receptors (ERRs) — specifically ERRα, ERRβ, and ERRγ.
It’s sometimes described in media / secondary sources as an “exercise mimetic” — meaning that, in animal studies, it produces some effects similar to those of aerobic exercise (improved endurance, increased mitochondrial function, increased fat oxidation) even without actual exercise.
Mechanism of Action
The ERRs (especially ERRα) are nuclear receptors that are important regulators of energy metabolism. They help control mitochondrial biogenesis, fatty acid oxidation, oxidative phosphorylation, etc.
By activating these receptors, SLU-PP-332 appears to shift cellular metabolism toward what resembles the effects of endurance training: more oxidative fibers, better mitochondria, increased energy expenditure, etc.
What Animal / Preclinical Studies Have Observed
From the available data (mostly in mice, some in cell culture), here are what have been some of the key findings:
Effect / What was observed
Weight / fat loss Obese mice treated with SLU-PP-332 lost weight, showed reduced adiposity, even though food intake did not drop.
Endurance / exercise capacity Mice ran further / longer when given the compound; improved resistance to fatigue.
Mitochondrial function / Increased mitochondrial activity, biogenesis, more efficient energy use in muscles.
Metabolic health / glucose homeostasis Improved insulin sensitivity, better glucose tolerance in animal models; improvements in markers of metabolic syndrome.
Tissue effects Some studies suggest benefits in other tissues (heart, liver, kidneys) in terms of reducing inflammation, improving mitochondrial health.
Bodybuilder-Relevant Uses
As a bodybuilder, here are ways SLU-PP-332 might be appealing
Possible Benefits
Increased Endurance / Better Recovery
By boosting mitochondrial function and oxidative capacity, it could allow you to do more high-rep training, recover faster, maybe tolerate more volume or conditioning work.
Fat Loss / Improved Metabolism
If it increases basal energy expenditure (i.e. more calories burned at rest), shifts toward fat oxidation, etc., it could help in leaning out phases while preserving more muscle (assuming diet/training is preserved).
Mitochondrial Health
Over time, better mitochondria may help with sustained energy, less fatigue, possibly less oxidative damage (which might help recovery/aging).
Prevent or Reduce Decline
In cutting phases, or long training cycles, or with age, when performance and metabolism tend to decline, something that mimics parts of what endurance training does could be helpful.
It’s sometimes described in media / secondary sources as an “exercise mimetic” — meaning that, in animal studies, it produces some effects similar to those of aerobic exercise (improved endurance, increased mitochondrial function, increased fat oxidation) even without actual exercise.
Mechanism of Action
The ERRs (especially ERRα) are nuclear receptors that are important regulators of energy metabolism. They help control mitochondrial biogenesis, fatty acid oxidation, oxidative phosphorylation, etc.
By activating these receptors, SLU-PP-332 appears to shift cellular metabolism toward what resembles the effects of endurance training: more oxidative fibers, better mitochondria, increased energy expenditure, etc.
What Animal / Preclinical Studies Have Observed
From the available data (mostly in mice, some in cell culture), here are what have been some of the key findings:
Effect / What was observed
Weight / fat loss Obese mice treated with SLU-PP-332 lost weight, showed reduced adiposity, even though food intake did not drop.
Endurance / exercise capacity Mice ran further / longer when given the compound; improved resistance to fatigue.
Mitochondrial function / Increased mitochondrial activity, biogenesis, more efficient energy use in muscles.
Metabolic health / glucose homeostasis Improved insulin sensitivity, better glucose tolerance in animal models; improvements in markers of metabolic syndrome.
Tissue effects Some studies suggest benefits in other tissues (heart, liver, kidneys) in terms of reducing inflammation, improving mitochondrial health.
Bodybuilder-Relevant Uses
As a bodybuilder, here are ways SLU-PP-332 might be appealing
Possible Benefits
Increased Endurance / Better Recovery
By boosting mitochondrial function and oxidative capacity, it could allow you to do more high-rep training, recover faster, maybe tolerate more volume or conditioning work.
Fat Loss / Improved Metabolism
If it increases basal energy expenditure (i.e. more calories burned at rest), shifts toward fat oxidation, etc., it could help in leaning out phases while preserving more muscle (assuming diet/training is preserved).
Mitochondrial Health
Over time, better mitochondria may help with sustained energy, less fatigue, possibly less oxidative damage (which might help recovery/aging).
Prevent or Reduce Decline
In cutting phases, or long training cycles, or with age, when performance and metabolism tend to decline, something that mimics parts of what endurance training does could be helpful.
