Fat Loss & Metabolic
Incretin mimetics and lipolytic peptides — the GLP-1 class and its relatives.
9 compounds
Fat Loss
Animal only5-Amino-1MQ
5-amino-1-methylquinolinium iodide · 5A1MQ
Oral NNMT inhibitor aimed at fat-cell metabolism and NAD+ salvage. Mouse data only.
- Dose
- 50–150 mg
- Frequency
- once daily
- Half-life
- —
Fat Loss
Human trialsAOD-9604
AOD9604 · Tyr-hGH(177-191)
Modified hGH tail fragment sold for lipolysis without the IGF-1 rise of growth hormone.
- Dose
- 250–500 mcg
- Frequency
- once daily
- Half-life
- 3 min
Fat Loss
Human trialsCagrilintide
AM833 · Cagri
Long-acting amylin analogue run weekly for satiety, usually alongside a GLP-1.
- Dose
- 0.3–4.5 mg
- Frequency
- once weekly
- Half-life
- 6.6 days
Fat Loss
Animal onlyHGH Fragment 176-191
HGH Frag · Frag 176-191
The C-terminal tail of growth hormone, sold for fat loss on almost entirely rodent evidence.
- Dose
- 125–500 mcg
- Frequency
- Once daily, fasted (many split it into two 250 mcg doses)
- Half-life
- —
Fat Loss
Human trialsLiraglutide
Lira · Victoza
Daily first-generation GLP-1 agonist; weaker and more injection-heavy than the weekly analogues.
- Dose
- 0.6–3 mg
- Frequency
- Once daily
- Half-life
- 13 h
Fat Loss
Human trialsRetatrutide
Reta · LY3437943
Investigational weekly triple GIP/GLP-1/glucagon agonist with the largest weight loss seen yet.
- Dose
- 1–12 mg
- Frequency
- Once weekly
- Half-life
- 6 days
Fat Loss
Human trialsSemaglutide
Sema · Ozempic
Long-acting GLP-1 agonist dosed weekly; the reference compound for appetite-driven fat loss.
- Dose
- 0.25–2.4 mg
- Frequency
- Once weekly
- Half-life
- 7 days
Fat Loss
Human trialsSurvodutide
BI 456906 · BI-456906
Weekly glucagon/GLP-1 dual agonist that raises energy expenditure as well as cutting appetite.
- Dose
- 0.3–6 mg
- Frequency
- once weekly
- Half-life
- 6 days
Fat Loss
Human trialsTirzepatide
Tirz · Mounjaro
Weekly dual GIP/GLP-1 agonist; beats semaglutide on total weight loss in head-to-head data.
- Dose
- 2.5–15 mg
- Frequency
- Once weekly
- Half-life
- 4.9 days