HPTA & Fertility
Gonadotropins and GnRH analogues used to restart or support natural testosterone production.
5 compounds
HPTA
Human trialsGonadorelin
GnRH · LHRH
Native GnRH decapeptide, now the usual compounded stand-in for hCG on TRT.
- Dose
- 100–400 mcg
- Frequency
- 1-2x daily
- Half-life
- 4 min
HPTA
Human trialshCG
HCG · Chorionic Gonadotropin
LH-mimic that keeps the testes producing while exogenous androgens shut the axis down.
- Dose
- 125–4000 IU
- Frequency
- Every other day, or 2-3x per week
- Half-life
- 23 h
HPTA
Human trialshMG
HMG · Menotropin
Urine-derived FSH plus LH activity, added to hCG when sperm counts will not recover.
- Dose
- 75–150 IU
- Frequency
- 3x per week
- Half-life
- —
HPTA
Early humanKisspeptin-10
KP-10 · Kp-10
Upstream GnRH trigger — the switch that makes the hypothalamus fire and the pituitary release LH.
- Dose
- 10–100 mcg
- Frequency
- 3x weekly on non-consecutive days
- Half-life
- 4 min
HPTA
Human trialsTriptorelin
Trelstar · Decapeptyl
Long-acting GnRH agonist taken as one microdose to fire off a large LH and FSH surge.
- Dose
- 50–100 mcg
- Frequency
- Single one-off dose
- Half-life
- 2.8 h