I stayed up half the night getting sucked in to the opioid/gyno post. Very interesting. I wrote down some notes of things that I have to research further. In one of the reference articles it mentions free test as being biologically active 10 minutes. Then the paper goes into esterfication and hx of HRT, yada, yada. I’m wondering if it was across the board. So free test is around until it attaches to a protein via AR, or binding protein, albumin…etc. So that says to me Even raising free test as much as possible and lowering shbg, there must be plenty of receptors on the different sites.