NeuroRN
ICU nurse/Moderator
I found this interesting and enlightening. Turns out it does a whole lot more than make you stand an salute. The more I learn the more I’m beginning the think of aging as any other disease and looking for ways to slow the disease process. This will be one I add to the mix.
CIALIS:
Cialis (Tadalifil) is a PDE5 inhibitor (i.e. a vasodilator, which describes a drug that ‘opens’ your blood vessels for increased blood flow). It is an FDA-approved medication in the USA for benign prostate hyperplasia(BPH), a condition where the prostate constantly grows in size as a man ages. Cialis can also treat high blood pressure, but it is marketed under the brand name Adcirca for this specific purpose. Additionally, it will help individuals with normal blood pressure who are looking to improve their current numbers .
What if we told you that Cialis can also reduce inflammation in the body? It has been proven to reduce C-reactive protein levels (one important biomarker of body inflammation), and in doing so, it drastically lowers the buildup of plaque in your arteries This also makes Cialis a cardio protective drug.
Unsurprisingly, there are breakthrough studies showing that Cialis has powerful protective effects against several clinical scenarios including myocardial ischemia/reperfusion injury, doxorubicin and post-MI, heart failure, cardiac hypertrophy and heart transplantation. In plain English, Cialis is clinically proven to help prevent heart disease and reduce the probability of heart attacks.
On top of all that, Cialis has been proven to increase lean muscle tissue in healthy aging males, while improving their testosterone-to-estrogen ratios. Because of these benefits, some men may be able to use a lower dosage of an AI medication if Cialis is also being taken at daily low doses. The less you have to rely on AI medications, the better results you will see with your HDL cholesterol levels and your bone mineral density as you get older.
Finally, a big fear of prescribing testosterone to patients is the fear of prostate enlargement Cialis is proven to relax the smooth muscles of the prostate, ultimately reducing any symptoms of BPH.
How Does It Work:
When a man is sexually stimulated, nitric oxide is released into the penis. Nitric oxide enables the production of cGMP (Cyclic guanosine monophosphate), which controls the dilation (opening) and contraction (closing) of the blood vessels that carry blood to and from the penis. Another substance, PDE5 (phosphodiesterase type 5 inhibitor), destroys cGMP. When this occurs, the blood vessels return to their normal size and the erection ends. Cialis stops PDE5 from destroying cGMP, thereby causing the erection to last longer.
Cialis also works by increasing nitric oxide formation throughout the entire body. This causes vasodilation (opening of blood vessels) and improved blood flow to many tissues, including the brain. The improved blood flow also provides a better ‘pump’ in the gym . In short, dosing Cialis at low levels will not only strengthen erections and protect the brain, but it will also improve exercise performance through vasodilation of the muscle cells.
Side Effects
Cialis, when used daily at low dosages, causes very few side effects. The reported side effects from taking too much Cialis include nausea, headache, flushing, dizziness, runny nose, indigestion, and muscle aches. Most of these side effects make sense, as dilating your blood vessels may cause your blood pressure to change. Therefore, a man who is already prescribed a nitrate drug for heart problems or chest pain should not use Cialis. Like any new drug you introduce into your daily regimen, consult with your physician and start at very low doses. It is highly unlikely that you will suffer any of the mentioned side effects if you use safe effective dosing.
Dosage:
2.5-7mg daily. With a up 30-40 mg dose if using it for sex. Then return to your regularly scheduled programming low dose.
This write up comes from one of my favorite books about trt and hormone optimization.
The following are the articles that back up the claims made.
SOURCES:
Hatzimouratidis K. A review of the use of tadalafil in the treatment of benign prostatic hyperplasia in men with and without erectile dysfunction. Therapeutic Advances in Urology. 2014;6(4):135-147. doi:10.1177/1756287214531639.
Safety and effectiveness of tadalafil in patients with pulmonary arterial hypertension: Japanese post-marketing surveillance data. Hiroyoshi Yamazaki, Noriko Kobayashi, Masanori Taketsuna, Koyuki Tajima & Masahiro Murakami.
Lee JW, et al. Serum High-Sensitivity C-Reactive Protein Levels and Response to 5 mg Tadalafil Once Daily in Patients With Erectile Dysfunction and Diabetes. Korean J Urol. 2013 Dec;54(12):858-64.
Kukreja RC. Sildenafil and cardioprotection. Curr Pharm Des. 2013;19(39):6842-7.
Aversa A, et al. Tadalafil improves lean mass and endothelial function in nonobese men with mild ED/LUTS: in vivo and in vitro characterization. Endocrine. 2017 Jun;56(3):639-648.
Aversa, A., Fittipaldi, S., Bimonte, V.M. et al. Tadalafil modulates aromatase activity and androgen receptor expression in a human osteoblastic cell in vitro model. J Endocrinol Invest. (2016) 39: 199. 0344-1.
Effectiveness of tadalafil 5 mg once daily in the treatment of men with lower urinary tract symptoms suggestive to benign prostatic hyperplasia with or without erectile dysfunction: results from naturalistic observational TadaLutsEd study. Bechara A, Casabe A, Rodriguez Baigorri G, Cobreros C.J. Sex Med. 2014 Feb; 11(2):498-505. Epub 2013.
Jacqueline K. Limberg, Katherine R. Malterer, J. Mikhail Kellawan, William G. Schrage, Brad W. Wilkins, Wayne T. Nicholson, John H. Eisenach, Michael J. Joyner, Timothy B. Curry. Phosphodiesterase-5 inhibition preserves exercise onset vasodilator kinetics when NOS activity is reduced. J Appl Physiol (1985). 2017 Oct 5:jap.00483.2017.
CIALIS:
Cialis (Tadalifil) is a PDE5 inhibitor (i.e. a vasodilator, which describes a drug that ‘opens’ your blood vessels for increased blood flow). It is an FDA-approved medication in the USA for benign prostate hyperplasia(BPH), a condition where the prostate constantly grows in size as a man ages. Cialis can also treat high blood pressure, but it is marketed under the brand name Adcirca for this specific purpose. Additionally, it will help individuals with normal blood pressure who are looking to improve their current numbers .
What if we told you that Cialis can also reduce inflammation in the body? It has been proven to reduce C-reactive protein levels (one important biomarker of body inflammation), and in doing so, it drastically lowers the buildup of plaque in your arteries This also makes Cialis a cardio protective drug.
Unsurprisingly, there are breakthrough studies showing that Cialis has powerful protective effects against several clinical scenarios including myocardial ischemia/reperfusion injury, doxorubicin and post-MI, heart failure, cardiac hypertrophy and heart transplantation. In plain English, Cialis is clinically proven to help prevent heart disease and reduce the probability of heart attacks.
On top of all that, Cialis has been proven to increase lean muscle tissue in healthy aging males, while improving their testosterone-to-estrogen ratios. Because of these benefits, some men may be able to use a lower dosage of an AI medication if Cialis is also being taken at daily low doses. The less you have to rely on AI medications, the better results you will see with your HDL cholesterol levels and your bone mineral density as you get older.
Finally, a big fear of prescribing testosterone to patients is the fear of prostate enlargement Cialis is proven to relax the smooth muscles of the prostate, ultimately reducing any symptoms of BPH.
How Does It Work:
When a man is sexually stimulated, nitric oxide is released into the penis. Nitric oxide enables the production of cGMP (Cyclic guanosine monophosphate), which controls the dilation (opening) and contraction (closing) of the blood vessels that carry blood to and from the penis. Another substance, PDE5 (phosphodiesterase type 5 inhibitor), destroys cGMP. When this occurs, the blood vessels return to their normal size and the erection ends. Cialis stops PDE5 from destroying cGMP, thereby causing the erection to last longer.
Cialis also works by increasing nitric oxide formation throughout the entire body. This causes vasodilation (opening of blood vessels) and improved blood flow to many tissues, including the brain. The improved blood flow also provides a better ‘pump’ in the gym . In short, dosing Cialis at low levels will not only strengthen erections and protect the brain, but it will also improve exercise performance through vasodilation of the muscle cells.
Side Effects
Cialis, when used daily at low dosages, causes very few side effects. The reported side effects from taking too much Cialis include nausea, headache, flushing, dizziness, runny nose, indigestion, and muscle aches. Most of these side effects make sense, as dilating your blood vessels may cause your blood pressure to change. Therefore, a man who is already prescribed a nitrate drug for heart problems or chest pain should not use Cialis. Like any new drug you introduce into your daily regimen, consult with your physician and start at very low doses. It is highly unlikely that you will suffer any of the mentioned side effects if you use safe effective dosing.
Dosage:
2.5-7mg daily. With a up 30-40 mg dose if using it for sex. Then return to your regularly scheduled programming low dose.
This write up comes from one of my favorite books about trt and hormone optimization.
The following are the articles that back up the claims made.
SOURCES:
Hatzimouratidis K. A review of the use of tadalafil in the treatment of benign prostatic hyperplasia in men with and without erectile dysfunction. Therapeutic Advances in Urology. 2014;6(4):135-147. doi:10.1177/1756287214531639.
Safety and effectiveness of tadalafil in patients with pulmonary arterial hypertension: Japanese post-marketing surveillance data. Hiroyoshi Yamazaki, Noriko Kobayashi, Masanori Taketsuna, Koyuki Tajima & Masahiro Murakami.
Lee JW, et al. Serum High-Sensitivity C-Reactive Protein Levels and Response to 5 mg Tadalafil Once Daily in Patients With Erectile Dysfunction and Diabetes. Korean J Urol. 2013 Dec;54(12):858-64.
Kukreja RC. Sildenafil and cardioprotection. Curr Pharm Des. 2013;19(39):6842-7.
Aversa A, et al. Tadalafil improves lean mass and endothelial function in nonobese men with mild ED/LUTS: in vivo and in vitro characterization. Endocrine. 2017 Jun;56(3):639-648.
Aversa, A., Fittipaldi, S., Bimonte, V.M. et al. Tadalafil modulates aromatase activity and androgen receptor expression in a human osteoblastic cell in vitro model. J Endocrinol Invest. (2016) 39: 199. 0344-1.
Effectiveness of tadalafil 5 mg once daily in the treatment of men with lower urinary tract symptoms suggestive to benign prostatic hyperplasia with or without erectile dysfunction: results from naturalistic observational TadaLutsEd study. Bechara A, Casabe A, Rodriguez Baigorri G, Cobreros C.J. Sex Med. 2014 Feb; 11(2):498-505. Epub 2013.
Jacqueline K. Limberg, Katherine R. Malterer, J. Mikhail Kellawan, William G. Schrage, Brad W. Wilkins, Wayne T. Nicholson, John H. Eisenach, Michael J. Joyner, Timothy B. Curry. Phosphodiesterase-5 inhibition preserves exercise onset vasodilator kinetics when NOS activity is reduced. J Appl Physiol (1985). 2017 Oct 5:jap.00483.2017.
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