I wouldn’t use Sema for anything other than diabetes. The new gen’s Tirz, Reta have much better safety profiles, as well as a whole host of positive net effects: decreased systemic inflammation, lower fasting glucose (obviously), improvement in sleep apnea, decrease LVH, and the list goes on. The interesting thing will be to see if those are all a result of massive weight loss or they will also show up in healthy populations using low dose.
I have seen quite a few top level competitors over on other forums using them low dose even during growth phase for the sugar and inflammation control.
Several have used them in prep and said they feel it will eradicate the need for stimulant fat burners etc in the future.
The biggest problems I see are when people ramp up doses too fast, have poor hydration, or eat like shit on them. That’s a recipe for GI problems all damn day.