Pyridoxal 5’-phosphate (P5P) is the active form of vitamin B6, and it plays a role in the regulation of prolactin, a hormone primarily responsible for lactation and other functions in the body.
P5P helps regulate prolactin through its involvement in the synthesis of dopamine, a neurotransmitter that inhibits prolactin secretion. Here’s how it works:
If taken before prolactin sides arise while using AAS it will negate the unwanted side effects, often times negating the use of Caber or Prami.
100mg daily is adequate support for a lot, but heavy users will see benefits in up to 300mg for a short duration during their prolactin prevention while they are “on.” 300mg would be ill advised for long term supplementation.
P5P helps regulate prolactin through its involvement in the synthesis of dopamine, a neurotransmitter that inhibits prolactin secretion. Here’s how it works:
- Dopamine Synthesis: P5P acts as a cofactor for the enzyme aromatic L-amino acid decarboxylase (AADC), which is involved in the conversion of L-DOPA to dopamine.
- Prolactin Inhibition: Dopamine, produced in the hypothalamus, is transported to the anterior pituitary gland, where it binds to dopamine D2 receptors on lactotroph cells. When dopamine binds to these receptors, it inhibits the secretion of prolactin.
- Regulation: By ensuring adequate dopamine synthesis, P5P indirectly helps maintain normal prolactin levels. If there’s a deficiency in P5P (or vitamin B6), dopamine production might be impaired, leading to elevated prolactin levels, which can result in conditions like hyperprolactinemia.
If taken before prolactin sides arise while using AAS it will negate the unwanted side effects, often times negating the use of Caber or Prami.
100mg daily is adequate support for a lot, but heavy users will see benefits in up to 300mg for a short duration during their prolactin prevention while they are “on.” 300mg would be ill advised for long term supplementation.
