After trying many prior options as a teen in high school, was put on accurate. That stuff is very strong as others mentioned. I felt like I had lizard skin on my face for a month or 2, but then bam everything cleared up and never really returned. Don’t have any experience using it during TRT or a cycle, so don’t know how the interactions may have. Probably as you mentioned stay away from orals that target the liver to metabolize to be safe, unless of course your TRT doc says otherwise.