Tren cough"
The exact mechanisms underlying the cause of the tren cough is not known. However, trenbolone acetate’s androgenic effect activates a variety of lipid-like active compounds which are called prostaglandins.[25] Many of these prostaglandins are inflammatory and vasoconstrictive. Prostaglandins are signalled through two varying pathways cyclooxygenase (COX) (Also known as: prostaglandin-endoperoxide synthase) and lipoxygenases (LOX) (also known as: EC 1.13.11.34, EC 1.13.11.33, etc.).[26] Vasoconstriction of the muscular wall of the bronchus in the lungs is what triggers this cough reaction[citation needed]. Trenbolone increases an inflammatory mediator peptide called bradykinin which facilitates the dilation of blood vessels[citation needed]. The bradykinin peptide is well known to promote a cough reaction associated with ACE inhibitor medications prescribed for hypertension.[27]