Blood-work: A Year in Review, advice needed, and a mea culpa

[Aude_Aliquid_Dignu]

Looking for feedback on these blood-work numbers and why the total test numbers are going down with similar dosage from last year while on TRT Pharmacy Test. Most of my year was spent rehabbing from a torn patella will trying to maintain muscle mass, then needing to recomp because of no cardio for 6 months. Is the drop in total test due to compound interaction, desensitisation, or something else? @NeuroRN @TG

I also want to extend a mea culpa to @Flashlabs. These numbers indicate that your gear was not the issue.

Marker	1/17/21	4/11/21	7/26/21	10/18/21	1/2/22
Alanine Aminotransferase (ALT)	-	-	-	31	63
Albumin	4	4.1	3.8	4.7	4.7
Aspartate Aminotransferase (AST)	-	-	-	39	75
Estradiol	51.1	82.7	34.7	<15	31.2
Free Testosterone	19	32	29	12	15
Hematocrit	-	49.5	-	54.6	53.8
Luteinizing Hormone (LH)	-	-	-	-	-
Prolactin	-	-	-	-	-
Prostate-Specific Antigen (PSA)	-	1.43	-	3.84	1.39
Sex Hormone-Binding Globulin (SHBG)	17.6	10.7	2.8	3	1.4
Total Testosterone	682	967	722	369	410
120mg Pharmacy Test wk	200mg SRX Test wk	150mg SRX Test wk	120mg Flash Test wk	120mg Pharmacy Test wk
-	300mg SRX Deca wk	108mg SRX Deca wk	108mg Flash Deca	90mg Parmacon Labs Deca
-	25mg Anavar day	20mg Winstrol day	50mg Anavar day	-
TB500 & BPC-157	low dose hGH day	low dose hGH day	-
100mg Clomid wk	175mg Clomid wk	75mg Clomid wk	100mg Clomid wk	100mg Clomid wk
-	1mg Arimidex wk	1mg Arimidex wk	1mg Arimidex wk	0.50mg Arimidex wk

 

[Dirtnasty]

So it’s seem if test is about same with flash and pharma maybe he wasn’t underdosed

 

[Aude_Aliquid_Dignu]

True, and thus the “mea culpa” i issued.

 

[Dirtnasty]

I just have missed it. Wonder if the clomid juat isn’t working as well as it was. Sucks either way

 

[NeuroRN]

1. Thank you, I appreciate the reach out to flash. Says a lot about a person to say hey I was wrong.
2. Did you get covid or the vaccine?

 

[Aude_Aliquid_Dignu]

1. Going by the data, the new numbers suggests something else is going on for sure.
2. Yes, I got the 1st vaccine in early October, and the 2nd in early November of this year. And it is likly I had Covid after Christmas as well.

 

[NeuroRN]

It’s actually quite possible the vaccine may have effected your levels. There’s some research showing it is tanking men’s test levels even those on HRT.

 

[Aude_Aliquid_Dignu]

Thanks man… Does anything else stand out to you on this, is the SHBG being so low an issue, or the increase in ALT and AST?

I had not considered COVID as a culprit. Wow, that is some serious shit to consider and made known!

Testosterone in males with COVID-19: A 7-month cohort study - PubMed.

 

[NeuroRN]

I can’t remember the normal SHBG levels but that is a pretty significant swing. Your liver appears to be working double time. And it’s angry about it.

If you’re not using glutathione I would. Tudca. NAC if you can find it. If you can’t check on alpha lipoid acid.

I would give your liver some love. No alcohol. No orals. Take multiple liver supports. Or take your concerns to the doc. Those are some heavy swings across the board.

 

[Stretch22]

That’s interesting. Do you know exact date you got it? It does seem like the10/18 bloods is where things start to swing

 

[Aude_Aliquid_Dignu]

It was the weekend after Xmas, more than likely.

Still need to look into the vaccine and any studies on it’s affect on levels.

 

[Stretch22]

I meant when you got 1st dose

 

[Poppy]

Those SHBG levels are worrisome. That can be an indicator of all kind of nasties.

Diabetes is a big one.

 

[NeuroRN]

Jay campbell Instagram has some strong anecdotal evidence being presented against the vaccine.

 

[Aude_Aliquid_Dignu]

Early October

 

[Stretch22]

This is interesting. I just started digging and am reading a study on LH damage from it. It mentions the potential cause as high angiotensin isn’t that what you were recommending the telmasartin for? Very interesting

 

[Outlawthing]

Low SHBG. Can be caused by lots of things insulin resistance diabetes too much hgh opiates. Liver disease extended anabolic use. Alcohol, any number of crazy meds. thing is when it’s low it hinders your body’s ability to use, transfer, convert, make different whore- moans. I’m gonna play devils advocate why is estrogen so low too much AI CRASHED ESTROGEN notice your test is higher when estro is lower when it’s low also liver is doing something. Pills, alcohol, is your iron high? I wonder my body rides on the high side of estrogen or a little high when I feel good when I get to low 30’s or less I feel like ass.

Drugs that Raise SHBG via Increasing Prolactin:

• Antipsychotics (both typical and atypical)
• Antidepressants (SSRIs, Tricyclics, MAO-Is)
• Xanax and Buspar
• H2 Antagonists (Cimetidine, Ranitidine)
• Morphine
• Some Antihypertensives

Drugs that Raise SHBG:

• Raloxifene (Evista)
• Tamoxifen
• Spironolactone
• Anticonvulsants (Phenytoin)
• Oral (but not transdermal) estradiol
• Ethinyl estradiol (oral contraceptives)
• Metformin
• Exogenous insulin in Type 2 DM
• Coffee!

Drugs that Suppress SHBG:

• Progestins
• Glucocorticoids
• Exogenous insulin in Type I DM

Genetics

• Some people have a genetic variation in their SHBG structure that slows or speeds its degradation leading to high or low levels. Current research projects are studying specific SHBG SNPs with regard to risk of Type 2 diabetes

 

[Jonny]

This referenced article suggests having Covid lowered testosterone in some men but there is no reference to the vaccine. Has any found any articles linking the vaccine to a similar condition? I haven’t been able to find anything

 

[Jonny]

Just saw this now. I’m going to read up on this.

I guess the question would have to be asked if the problem is really men with lower test tend to be more obedient and got the vaccine?

 

[NeuroRN]

I recommend telmisartan in general. Probably up there with metformin in terms of longevity drugs.