I think it’s been about 4 days, but this hgh is high quality, I was running about 3 to 4 iu a day I think the water retention and the cartilage repair is the culprit. So I’ll just run 1 iu for a while then work my way up to about 2 and I’ll probably start back up Monday. I was pretty exhausted from it to lol I was napping everyday.