Embarrassing but I need to ask alternative ED treatments?

[PeteGrimkowsky]

Holy shit that’s scary man.

 

[Bigmurph6]

Yeah it wasn’t a good month. I honestly though feel better now than I have in 3yrs. That stuff I took for just over a year complained the entire time to my doctor and he still kept pushing it on me I wouldn’t have ever taken it honestly.

 

[Poppy]

That was poison to you brother.

 

[Dirtnasty]

Oral

 

[PeteGrimkowsky]

I simply do not understand why Doctors refuse to listen when patients try to advocate for themselves - and in this case, repeatedly saying a drug is making things worse… sorry you had to go through that man.unreal

 

[Bigmurph6]

Its crazy because I trust my doctor 100% that’s the only reason I continued it and then I realized that fuck trust I had to just stop.
It is fucked up that he did that to me and I definitely let him know how unhappy I really was after having a seizure I tore him a new asshole.
I won’t ever again mess with meds like those.

 

[NeuroRN]

I think there’s a few peptides out there that are being used with men and women. Pt-141 maybe? It’s actually being used by doctors.

 

[Bigmurph6]

For ED treatment? Or something else

 

[NeuroRN]

ED and “sexual dysfunction disorders” which covers all the spectrum. It’s worth a look? I haven’t done a ton of research into it. A girl at work has talked about it, not sure of her specific needs for it but it got me curious and I read more than once place talking about men using it.

 

[herrubermensch]

It’s the rank hubris of doctors: They always believe they know better and that their patients are ignorant and dumb and should do what they say. The doctors I use all know that I can run circles around them intellectually and so treat me as an equal. But ALL doctors should do that; none of them should have a “God” complex, but they almost all do.

 

[herrubermensch]

I have tried PT-141, and it absolutely works as advertised. One to two hours after you take it, you feel like you will die if you do not have sex, and the erections follow. It lasted for me a somehwat uncomfortable six hours–three of which were AFTER I had sex with my wife. It also has some tough sides–a little nausea at first and a head rush, then this weird need to stretch continuously. I haven’t done it since, but it absolutely is desire and erection in a can.

 

[Bigmurph6]

I appreciate it I will find out about it

 

[Bigmurph6]

Interesting
Im definitely going to look into it deeply and see what its all about

 

[Bigmurph6]

@NeuroRN @herrubermensch

Quick research

Bremelanotide, sold under the brand name Vyleesi, is a medication used to treat low sexual desire in women. Specifically it is used for low sexual desire which occurs before menopause and is not due to medical problems, psychiatric problems, or problems within the relationship. It is given by an injection just under the skin of the thigh or abdomen. Common side effects include nausea, pain at the site of injection, and headache. It may also cause a temporary increase in blood pressure and decrease in heart rate after each dose, and darkening of the gums, face, and breasts. The medication is a peptide and acts as an activating the melanocortin receptors. Bremelanotide was approved for medical use in the United States in 2019. It was developed by Palatin Technologies. The U.S. Food and Drug Administration considers it to be a first-in-class medication.

Its kinda crazy its made strictly for women but works in men?? I will find out lol

 

[NeuroRN]

So I believe it originally came from one of the melatotan peptides… and then it caused increase in sexual desire… so they isolated the sequence that caused the increase in sexual desire.

And that has a LOT to do with marketing.

 

[Bigmurph6]

Im amazed that a peptide actually was approved by the FDA its crazy. There calling it female viagra. The ugl labs are claiming that it works for both men and women but I need to find out why the FDA didn’t approve it for Male use.

 

[NeuroRN]

That would definitely be a good place to start! I hope it’s something dumb and it works great.

 

[Bigmurph6]

PT-141: a melanocortin agonist for the treatment of sexual dysfunction - PubMed

PT-141, a synthetic peptide analogue of alpha-MSH, is an agonist at melanocortin receptors including the MC3R and MC4R, which are expressed primarily in the central nervous system. Administration of PT-141 to rats and nonhuman primates results in penile erections. Systemic administration of...

pubmed.ncbi.nlm.nih.gov

Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic properties and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mild-to-moderate erectile dysfunction - PubMed

PT-141, a cyclic heptapeptide melanocortin analog, was evaluated following intranasal administration in healthy male subjects and in Viagra-responsive erectile dysfunction (ED) patients. Erectile response was assessed by RigiScan trade mark in healthy subjects without visual sexual stimulation...

pubmed.ncbi.nlm.nih.gov

Co-administration of low doses of intranasal PT-141, a melanocortin receptor agonist, and sildenafil to men with erectile dysfunction results in an enhanced erectile response - PubMed

Co-administration of intranasal PT-141 and a phosphodiesterase type 5 inhibitor may constitute a treatment alternative for patients in whom higher doses of a single therapy are not effective or well tolerated.

pubmed.ncbi.nlm.nih.gov

Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra - PubMed

PT-141, a cyclic heptapeptide melanocortin analog, was evaluated following subcutaneous administration to healthy male subjects and to patients with erectile dysfunction (ED) who report an inadequate response to Viagra. An inadequate response was defined for this study by patient report...

pubmed.ncbi.nlm.nih.gov

 

[Poppy]

Is this carried by an UGL?

 

[NeuroRN]

So it worked for rats, those who respond to viagra, those who don’t, and the best response with minimal side effects was minimal viagra and minimal pt-141.