Summary “ Although its exact mode of action is not known, gabapentin appears to have a unique effect on voltage‐dependent calcium ion channels at the postsynaptic dorsal horns and may, therefore, interrupt the series of events that possibly leads to the experience of a neuropathic pain sensation.“
Haha told you. The brain is beyond frustrating because we know so little about it. Basically it lowers action potential and decreases spasm in the neurons which potentially has some carry over to headaches. On “uptodate” website (where all the docs and NP’s go when they don’t know the answer, it seemed to have a 50/50 split in effectiveness of headache treatment. Made it to stage two trials for headaches but the data was statistically insignificant.
The good news: if you want to try it again it shows no interactions with any medications we know of, and it looks like antacids specifically H2 receptor blockers (Zantac, Tagamet) cause it to stay in the body longer. So if you want to try it again, you got a 50/50 shot with minimal drug interaction.
But from what I’ve seen it either works for folks or it doesn’t for headaches.